Aqualyx
Aqualyx Dosage and Administration Instructions
Jun 26, 2025
Fat cells, or adipocytes, are not just passive storage units for energy—they play a crucial role in regulating metabolism, hormones, and inflammation. A 2024 study from Cornell University highlights the dynamic nature of fat cells, which can expand or multiply in response to environmental and dietary influences. This complexity makes targeted fat reduction a nuanced process that requires precision.
One such method gaining traction in the field of body contouring is Aqualyx, an injectable solution that targets localized fat. Administered in controlled doses to specific areas, Aqualyx offers a non-invasive approach to sculpting the body. The treatment is carefully customized for each patient, with sessions spaced out to ensure gradual, noticeable results.
In this article, we will dive into the dosage and administration of Aqualyx, outlining how the treatment works, what patients can expect, and how to ensure safe and effective outcomes for targeted fat reduction.
Key Takeaways
- Aqualyx is an injectable treatment for localized fat reduction, using sodium deoxycholate as its active ingredient to break down fat cells through a process called adipocytolysis.
- Aqualyx’s formulation uses a gel-based matrix, which stabilizes the active ingredient and ensures controlled release. This minimizes irritation and side effects while delivering consistent results.
- Treatment areas include the chin, abdomen, flanks, and thighs. Dosage varies by area and fat thickness, with typical session volumes ranging from 8 to 32 mL. The number of sessions required varies by area, with 2-4 sessions typically needed for the chin, 4-8 sessions for the abdomen, and 3-6 sessions for the flanks and thighs.
- Proper injection technique is critical to minimize risks like skin irritation and nerve injury. The grid technique and proper subcutaneous injection depth help ensure even distribution and avoid complications.
- Sessions should be spaced 4 to 6 weeks apart to allow for proper fat metabolism and recovery. Follow-up care, including massage and lymphatic drainage, may be recommended if swelling persists.
- Aqualyx is not intended for general weight loss but for targeted fat reduction. It is most effective for individuals with localized fat that does not respond well to exercise or diet.
- Training in proper injection techniques and understanding the behavior of the active ingredient are essential for achieving safe and effective results.
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Preparation: Vial Concentration & Reconstitution Needs
Each vial of Aqualyx contains a pre-formulated solution with approximately 75 mg/mL sodium deoxycholate, the Aqualyx active ingredient. This formulation is designed as a gel-based aqueous matrix for stability and controlled dispersion. Unlike powdered agents, Aqualyx does not require reconstitution, which makes it more convenient for clinical use.
Steps in Preparing the Product
- Check the expiry date and vial integrity before use.
- Shake gently if separation occurs; however, the product is generally homogeneous.
- Withdraw the required dose using a Luer-lock syringe for secure cannula attachment.
- Use a blunt-tip cannula (typically 25G to 27G) with an appropriate length for the target area.
- Maintain sterile technique throughout the handling process.
- Storage should be kept between 2°C and 25°C, avoiding freezing or exposure to direct sunlight.
Dosage Guidelines by Area: Chin, Abdomen, Flanks, Thighs
Aqualyx dosage can vary significantly depending on the treatment area, fat thickness, and individual patient goals. The amount injected should always be tailored to the specific needs of the patient for optimal results. For each region, the following guidelines outline typical dosage ranges for commonly treated areas:
Chin (Submental Area)
- Typical dose: 1.5 mL to 2.5 mL
- Use a fan technique for even distribution
- Requires 2–4 sessions depending on fat volume
Abdomen (Upper & Lower)
- Typical dose: 8 mL to 10 mL per session (note the wide variability, doses can sometimes range from 8 to 32 mL per session)
- Can be divided across 2–3 injection sites
- Requires 4–8 sessions, depending on fat volume
Flanks (Love Handles)
- Typical dose: 4 mL to 6 mL per flank
- Inject bilaterally using lateral entry points
- Plan for 3–6 sessions
Thighs (Inner or Outer)
- Typical dose: 6 mL to 8 mL per thigh
- Divide into upper and lower segments for even application
- 4–6 sessions typically required
Important note: The Aqualyx active ingredient is potent, so it’s essential to continually assess the patient’s fat layer thickness and adjust doses accordingly. Do not exceed 10 mL per treatment zone in one session for safety.
Injection Technique: Grid, Depth & Spacing Protocols
Proper injection technique is essential for maximizing Aqualyx’s effectiveness while minimizing risks. Adherence to these protocols ensures precise product placement, even fat distribution, and a safer procedure.
Grid Pattern Application
- Create a treatment map using a 1–1.5 cm grid.
- Inject at each grid point for even distribution.
- Helps avoid over- or under-treatment in specific areas.
Injection Depth
- The cannula should remain within the subcutaneous plane.
- Avoid superficial injections to reduce the risk of nodules or skin irritation.
- Use ultrasound guidance if available for precision.
Spacing & Cannula Movement
- Move the cannula in a fan-shaped pattern within the treatment zone.
- Multiple retrograde linear threads can improve product dispersion.
- Always aspirate before injecting to avoid intravascular placement.
Aqualyx is not intended for intramuscular or dermal use. Precise depth control is essential to avoid adverse outcomes, and training is necessary to ensure the best results.
Treatment Planning: Sessions, Spacing & Follow-up
Effective fat reduction with Aqualyx requires a well-structured treatment plan tailored to the patient’s goals and anatomy. Here’s a practical overview of how to structure an effective Aqualyx treatment schedule:
Number of Sessions
- Chin: 2–4 sessions
- Abdomen: 4–8 sessions
- Flanks and thighs: 3–6 sessions
- Evaluate fat thickness after every two sessions to adjust dosage if necessary.
Session Spacing
- Maintain a gap of 4 to 6 weeks between each session.
- This allows for inflammation resolution and the complete metabolic processing of fat debris.
Follow-up Care
- Check patient response 6–8 weeks after the final session.
- Recommend massage and lymphatic drainage if swelling persists.
- Remind patients that Aqualyx is not a weight loss solution—it targets localized fat.
- Long-term maintenance may require yearly follow-ups, especially if the patient experiences weight fluctuations.
Conclusion
Administering Aqualyx safely and effectively depends on proper dosage calculations, anatomical awareness, and adherence to injection protocols. The pre-mixed solution simplifies preparation, while the flexible dosing approach allows for customization for various body areas. With proper spacing and consistent technique, Aqualyx can achieve gradual but noticeable fat reduction in localized areas.
Practitioners must ensure they are trained in injection techniques specific to Aqualyx and understand the unique behaviors of deoxycholic acid-based treatments. Regular evaluation, correct session planning, and patient follow-up will help improve both results and patient satisfaction.
FAQs
1. Can Aqualyx be diluted before use?
No, Aqualyx is a ready-to-use product and should not be diluted. The 10 mg/mL formulation is pre-measured.
2. Is Aqualyx safe for all body types?
It is designed for localized fat pockets in healthy individuals. It is not suitable for obese patients or systemic fat reduction.
3. How long do results take to show?
Most patients experience gradual changes after two sessions, with final results becoming visible 6–8 weeks after the last treatment.
4. Can an aesthetician combine Aqualyx with other fat-reduction treatments?
Yes, they can combine Aqualyx with other body contouring methods, such as radiofrequency or cavitation, but they should also carefully manage timing.
5. Are there risks or side effects?
Common side effects include swelling, bruising, tenderness, and mild nodules. Serious complications are rare as long as the administering professional uses proper technique.
6. Is Aqualyx suitable for facial fat reduction?
Clinicians mainly use it to target submental fat. Use on other facial areas is off-label and requires expert skill.
7. Do patients need lifestyle changes for better results?
While not mandatory, maintaining a healthy diet and exercise can help sustain and enhance results after treatment.
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References
Groff E. New molecular nutrition research helps explain how fat cells develop. Cornell College of Human Ecology. Published January 19, 2024. https://www.human.cornell.edu/news/imported/2024/01/new-molecular-nutrition-research-helps-explain-how-fat-cells-develop
Baldelli S, Aiello G, Di Martino EM, Campaci D, Muthanna FMS, Lombardo M. The role of adipose tissue and nutrition in the regulation of adiponectin. Nutrients. 2024;16(15):2436. doi:10.3390/nu16152436
Nall R. About Aqualyx Fat-Dissolving Injections. Healthline. Published December 12, 2020. https://www.healthline.com/health/aqualyx
Deoxycholic acid dosage guide + Max dose, adjustments. Drugs.com. https://www.drugs.com/dosage/deoxycholic-acid.html
