EMLA cream
EMLA Cream – How Long Does It Last?
Jul 28, 2025
Topical numbing creams are often used to alleviate discomfort during minor procedures, such as injections, skin treatments, or laser sessions. They work by temporarily blocking pain signals in the skin, and where you apply them really matters. Areas such as the lips, inner cheeks, and genitals respond quickly due to their thin, sensitive skin and dense nerve supply.
EMLA cream is one of the most widely used options for numbing intact skin. It combines two local anesthetics, lidocaine and prilocaine, to create a temporary numbing effect. While it doesn’t kick in immediately, it offers relief that can last for up to a couple of hours, depending on factors like skin thickness, how long it’s left on, and whether it’s covered with a dressing.
In this article, we’ll break down how long EMLA cream lasts, what affects its numbing power, and how to use it safely and effectively for the best results.
Key Takeaways
- EMLA cream is a topical anesthetic composed of lidocaine and prilocaine, used to numb the skin prior to minor medical or cosmetic procedures.
- On intact skin, EMLA typically begins to take effect after 60 minutes and provides numbness for approximately 1 to 2 hours after removal.
- On mucosal surfaces (like the genitals), the cream acts faster—usually within 5 to 10 minutes—but the numbing effect may wear off more quickly.
- Factors such as skin thickness, dosage, application time, and the use of occlusive dressings all influence both the onset and duration of effect.
- To maximize the benefits of EMLA, apply the recommended amount, cover it properly (if advised), and wait the full onset time before starting the procedure.
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When Does EMLA Cream Start Working? Understanding Onset Time
EMLA cream begins working differently depending on the type of skin it’s applied to. For intact skin, the full numbing effect typically takes about 60 minutes to develop. Shorter times, like 20–30 minutes, are not clinically reliable. However, when used on mucosal surfaces, such as the genital area, the onset is much quicker, usually within 5 to 10 minutes. This difference is key for timing procedures correctly and safely.
Several factors can influence the timing of the effect:
- Skin Thickness: Thicker skin, such as on the back, requires more time for the cream to absorb.
- Occlusion: Covering the cream with a proper dressing speeds up absorption and boosts effectiveness.
- Dose Applied: Using less than the recommended amount may lead to delayed or incomplete numbing.
- Skin Condition: Absorption is more consistent on healthy, unbroken skin. So, if you’re wondering, can you put EMLA cream on a burn? The answer is no, unless a healthcare provider specifically tells you to. Damaged or inflamed skin can increase risks and alter how the cream works.
For intact skin, always plan for a full hour before beginning any procedure unless directed otherwise by a medical professional.
How Long EMLA Cream Lasts on Different Parts of the Body
Once the numbing effect kicks in, EMLA cream usually lasts 1 to 2 hours, depending on where it’s applied. Areas with thinner skin or more blood flow may feel numb for a shorter time, while thicker areas hold the effect longer. This helps patients and providers better plan procedures and comfort windows.
Here’s a general guide by body area:
- Arms or Legs: 1.5 to 2 hours
- Face: 30 to 60 minutes
- Back or Chest: 1 to 1.5 hours
- Genital Area (mucosal): 20 to 45 minutes
- Hands or Feet: Around 1 hour
Mucosal surfaces absorb the cream faster, but they also lose the numbing effect sooner. Conversely, thicker areas like the upper arms or back require more time for onset but tend to remain numb longer. Always follow medical guidance specific to the treatment area for best results and patient safety.
Factors That Affect the Duration of EMLA’s Numbing Effect
The duration of EMLA cream’s effects isn’t the same for everyone. A few key factors can make it last longer (or shorter) than expected:
- Skin Thickness: Thicker skin slows absorption but holds the numbing effect longer.
- Amount Applied: Too little may reduce effectiveness; too much may increase the risk of side effects.
- Time Left On Skin: Under- or over-applying in terms of duration can compromise results or increase risk.
- Occlusion: Using a dressing enhances absorption and extends the effect.
- Body Temperature: Warmer areas may absorb faster, but wear off faster too.
- Hydration: Moisturized skin may absorb more evenly than dry patches.
- Age & Circulation: Older adults or those with poor circulation might see altered timing and results.
By considering these variables, users can optimize their EMLA application for both safety and success.
Best Practices for Using EMLA Cream Before Procedures
To get the most from EMLA cream, it’s essential to follow proper application steps. These best practices not only ensure effectiveness but also reduce the risk of irritation or underperformance.
How to apply EMLA:
- Clean the skin thoroughly to remove any dirt, oil, or creams.
- Apply the correct amount of cream to the specific body area and procedure.
- Cover it with an occlusive dressing to trap the medication and improve absorption.
- Wait the full recommended time: 60 minutes for intact skin unless instructed otherwise.
- Remove the cream completely and gently clean the area before the procedure begins.
- Monitor the site for any signs of redness, irritation, or adverse reactions.
Avoid reapplying the cream without guidance, and never use it on burns or broken skin unless advised by a healthcare provider.
Conclusion
EMLA cream is a trusted and effective way to manage pain during minor procedures—but only when used correctly. It takes about 60 minutes to work on intact skin and around 5–10 minutes on mucosal surfaces, with the numbing effect lasting up to two hours in most areas.
Following application guidelines, using occlusion, and avoiding misuse on damaged skin (such as EMLA cream on a burn) ensures better comfort and safety. Always consult a healthcare professional for personalized advice.
FAQs
1. How long does EMLA cream last after removal?
Typically, the numbing effect lasts for 1 to 2 hours after the cream is wiped off.
2. Can I leave EMLA cream on longer than 60 minutes?
Only if advised by a healthcare provider. More prolonged exposure may increase the risk of side effects.
3. Does the numbing effect wear off faster on the face?
Yes, facial skin absorbs EMLA quickly, but the numbing effect also fades faster, often within 30 to 60 minutes.
4. Can I reapply EMLA cream if the effect wears off?
Not without professional advice. Reapplication may cause skin irritation or systemic side effects.
5. Do I need to use a dressing over the cream?
Yes, covering the cream helps it absorb more effectively and speeds up the onset time.
6. How do I know EMLA is working?
You may notice slight skin blanching, tingling, or reduced sensation in the area.
7. Is there a difference in duration between adult and pediatric use?
Yes, children have thinner skin and may experience faster onset and shorter duration. Always follow pediatric-specific instructions.
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References
Sobanko JF, Miller CJ, Alster TS. Topical Anesthetics for Dermatologic Procedures: A review. Dermatologic Surgery. 2012;38(5):709-721. doi:10.1111/j.1524-4725.2011.02271.x
EMLA CREAM (Lidocaine 2.5% and Prilocaine 2.5%). https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019941s021lbl.pdf
