dermal fillers
Fillers With NASHA Technology: Expert’s Guide
Aug 25, 2025
NASHA technology (Non-Animal Stabilized Hyaluronic Acid) is one of the most consistent and versatile dermal filler technologies, employed by clinicians all over the world.
Developed by Galderma, NASHA technology fillers are highly regarded for being safe, predictable, and clinically effective, and therefore a standard in facial rejuvenation and volume restoration procedures. To medical professionals seeking consistency of outcome in patients, an understanding of NASHA technology is imperative. From Restylane fillers to skin boosters and even orthopedic applications like Durolane, NASHA has a wide range of solutions to meet the demands of treatments.
This article explores what NASHA technology is and how it works in aesthetic treatments.
Key Takeaways
- NASHA technology is the foundation behind several Restylane fillers, including Restylane Lyft, and Restylane SkinBoosters.
- NASHA technology Restylane creates safe, long-lasting, and natural-feeling dermal fillers through minimal crosslinking, uniform gel particle design, and non-animal sourced hyaluronic acid.
- NASHA fillers are renowned for their lifting, tissue integration, and duration, and are therefore ideal for facial rejuvenation, volumization, and hydration.
- In addition to aesthetic range, Durolane, which is also formulated through the use of NASHA, demonstrates the broad medical applications of the technology.
At Maylips, practitioners can access a full range of Restylane fillers containing NASHA technology to address diverse patient requirements.
RESTYLANE® 1ml with Lidocaine
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RESTYLANE® LYFT with Lidocaine
£98.00
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What is NASHA Technology?
NASHA (Non-Animal Stabilized Hyaluronic Acid) technology is Galderma’s proprietary technique for producing hyaluronic acid (HA) fillers. Unlike naturally occurring HA, which is rapidly degraded, NASHA undergoes minimal chemical crosslinking to maintain:
- Biocompatibility (closely mimicking natural HA)
- Consistency (regular gel firmness, particle uniformity)
- Longevity (lasting 6–12 months depending on placement)
This innovation was the foundation for the first Restylane family of fillers, the first HA filler ever approved by the FDA in the United States in 2003 and in China by the National Medical Products Administration (NMPA) in 2008. The concept behind NASHA technology is the low chemical modification of hyaluronic acid chains. By precisely stabilizing HA with a minimum number of crosslinks, Galderma developed a filler material very similar to the body’s own HA, minimizing the risk of immune response.
Simultaneously, this methodology produces regular gel firmness, providing practitioners with increased control over aesthetic results. It is frequently recognized by clinicians through its particulate gel structure. The unique gel texture provides control in sculpting and lifting tissue, so NASHA Technology fillers are very utilized in structural cases such as cheek augmentation, nasolabial folds, and definition of the jawline. It is this structural reliability that makes NASHA remain one of the most dependable technologies in aesthetic medicine.
How NASHA Technology Works in Dermal Fillers
NASHA technology reorganizes naturally occurring hyaluronic acid (HA) into a stabilized form that is safe for application in medicine. The process improves stability, safety, and reproducible results in aesthetic treatments. The key elements in the mechanism of action of NASHA Technology are:
Crosslinking Process
At the basis of NASHA technology lies a limited crosslinking process, whereby a minimal amount of crosslinking agent is used to connect hyaluronic acid (HA) chains. This creates a solid yet resilient gel to rapid enzymatic degradation in the skin. By keeping the crosslinking to a minimum, the gel retains much of the native configuration of HA, thereby creating fillers that closely mimic the body’s own hyaluronic acid in texture and function. This yields a filler that balances duration with natural feel and appearance.
Particulate Gel Design
Another innovative feature of NASHA technology is the particulate gel design. Each filler contains monosized gel particles, meaning they are identical in size and specifically designed for different clinical applications. For example, larger particles are better suited for deeper volume augmentation, while smaller ones work well for fine lines or more superficial locations. This design provides physicians with flexibility and precision when individualizing treatment based on individual patient needs.
Longevity
The duration of Galderma NASHA technology is among the reasons why they are dependable in clinical practice. Effects, based on the product utilized and area treated, may last for 6 to 12 months. This longevity is due to the gel’s resistance to degradation as well as how effectively it becomes incorporated into the surrounding tissue. Patients can therefore enjoy long-lasting aesthetic benefits over time without the need for frequent re-treatments.
Safety Profile
NASHA technology relies on hyaluronic acid from a non-animal source, reducing the risks of allergic reactions or immunological reactions. Since HA is a naturally occurring substance in the human body, the body readily accepts it, and the treatment becomes safer for the vast majority of patients. This excellent safety profile has been developed through decades of clinical use, inspiring patient confidence and practitioner trust.
Key Benefits of NASHA Technology in Aesthetic Medicine
NASHA fillers have been widely appreciated for their clinical reliability and consistent results. Their benefits have led to them being one of the most preferred options both in general and specialized aesthetic centers.
Control and Precision
Because NASHA Technology maintains a constant particle size, physicians can sculpt and elevate with remarkable accuracy. This precision makes it particularly effective for structural applications such as cheek augmentation, jawline contouring, and the correction of deep nasolabial folds, where symmetry and balance are needed.
Natural Results
The particulate gel integrates seamlessly with surrounding tissues, providing both volume and definition while avoiding unnatural firmness or overcorrection. This characteristic is especially valued in lip augmentation (vermillion border and perioral lines) and tear trough correction, where subtle, natural-looking outcomes are critical.
Long-Lasting Results
Stabilized hyaluronic acid from Restylane fillers maintains its effect for 6–12 months, depending on placement and formulation. This durability makes it a preferred option for treatments such as chin projection, midface volumization, and marionette line correction, reducing the need for frequent retreatments.
Safety and Biocompatibility
Formulated with non-animal stabilized HA, NASHA Technology significantly reduces the risk of allergic or immunological reactions. Its excellent safety record, demonstrated in over 50 million global treatments, makes it a dependable choice for first-time filler patients, delicate lip treatments, and superficial fine line corrections where safety is paramount.
Clinical Applications of NASHA Technology Fillers
The versatility of NASHA-based fillers is reflected in their ability to address multiple aesthetic indications across the face. In wrinkle correction, for example, Restylane LYFT is highly effective for managing moderate to severe lines such as nasolabial folds and marionette lines.
In correcting infraorbital hollows (tear trough deformities), Restylane EYELIGHT is preferred. Similarly, jawline definition benefits from the larger-particle NASHA gels, which deliver the structural support needed for sharper, more contoured lower face aesthetics.
Finally, beyond contouring and volumization, Restylane SkinBoosters play a unique role in skin hydration and rejuvenation by improving elasticity, reducing fine lines, and enhancing overall dermal radiance.
Beyond cosmetic beauty, NASHA Technology Durolane demonstrates its versatility in orthopedic medicine. Durolane, an injectable stabilized HA derived from NASHA technology, is widely used to relieve the symptoms of knee osteoarthritis, highlighting the broader medical applications of this innovation.
Popular Products that Use NASHA Technology
The Restylane NASHA Technology was the initial dermal filler range produced with NASHA technology. However, Galderma’s NASHA portfolio extends beyond facial fillers, offering solutions that address both aesthetic and medical needs. Below is a comparison of the most commonly used products developed with this technology:
| Product | Key Indications | Unique Features |
| 1. Restylane | Moderate to severe facial wrinkles and folds (e.g., nasolabial folds); also lip injections | Firm gel texture engineered for lift and precision; provides structural support and projection |
| 2. Restylane EYELIGHT | Tear trough correction (under-eye hollows) | Low hygroscopicity; clinically developed for under-eye precision and natural results |
| 3. Restylane LYFT | Cheek augmentation, chin projection, deep folds | Large particle size; strong lifting capacity |
| 4. Durolane | Osteoarthritis (knee and other joints) | Single-injection HA therapy; long-lasting pain relief |
Conclusion
For more than 20 years, NASHA technology has been a cornerstone of aesthetic medicine. Its balance of safety, precision, and natural results makes it one of the most dependable filler technologies available.
By integrating NASHA-based fillers, clinicians can expand treatment options with confidence, supported by decades of research and millions of successful patient outcomes.
FAQs
1. What is NASHA technology in dermal fillers?
NASHA technology (Non-Animal Stabilized Hyaluronic Acid) represents Galderma’s proprietary method of producing stabilized hyaluronic acid gels.
2. Which of the Restylane products have NASHA technology?
Several of the Restylane products have NASHA, including Restylane Lyft, Restylane-L, Restylane Silk, and Restylane SkinBoosters.
3. Is NASHA technology extendable beyond aesthetics?
Yes. Another product from the NASHA technology, Durolane, is applied for the treatment of symptomatic osteoarthritis of large joints such as the knee.
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References
- Ohrlund A, Winlof P, Bromee T, Prygova I. Differentiation of NASHA and OBT hyaluronic acid gels according to strength, flexibility, and associated clinical significance. J Drugs Dermatol. 2024;23(1):1332–1336. doi:10.36849/JDD.7648
- Galderma. The science behind Restylane. Galderma Aesthetics. Accessed August 19, 2025. https://www.galdermaaesthetics.com/science-behind-restylane
- Nikolis A, et al. Effectiveness and safety of a new NASHA-HD hyaluronic acid injectable, HASHA, for augmentation and correction of chin retrusion. Presented at: 25th International Master Course on Aging Science (IMCAS) World Congress; January 25-27, 2024; Paris, France.
