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Profhilo vs Jalupro – A Thorough Comparison


Profhilo
Published by Andrea Stearns
Last Updated On May 28, 2025

Profhilo vs Jalupro – A Thorough Comparison

May 24, 2025

Hyaluronic acid (HA) is renowned for its vital role in maintaining skin hydration and addressing signs of aging. Scientific research confirms that HA not only enhances moisture retention but also stimulates collagen synthesis, making it a cornerstone ingredient in modern cosmetic treatments. Its ability to improve skin elasticity and smooth wrinkles has made HA-based injectables a popular choice for restoring youthful volume and radiance.

Among the top HA-based injectables are Jalupro and Profhilo, each designed to improve skin quality but through distinct mechanisms. Jalupro emphasizes biorevitalization by combining HA with amino acids to nourish and rejuvenate the skin, while Profhilo delivers intense hydration and triggers natural collagen production for gradual skin remodeling. Understanding these differences in composition, application, and expected results is crucial for selecting the most suitable treatment.

This article provides a comprehensive comparison of Jalupro vs Profhilo, detailing their unique benefits, treatment protocols, and patient experiences to help readers make informed decisions about their aesthetic options.

Key Takeaways

  • Jalupro combines non-crosslinked hyaluronic acid with amino acids to stimulate collagen regeneration, targeting early signs of aging, such as fine lines, dullness, and uneven texture.
  • Profhilo consists of pure hyaluronic acid in a hybrid complex that provides deep hydration and promotes collagen and elastin production, making it ideal for addressing skin laxity and firmness without adding volume.
  • Jalupro is suited for patients seeking gradual improvements and prevention, commonly used on the face, neck, hands, décolletage, and stretch marks.
  • Profhilo works quickly to improve skin hydration and elasticity, typically requiring fewer sessions and treating larger areas, such as the cheeks, jawline, and neck.
  • Both treatments have excellent safety profiles, with mild side effects, such as redness, swelling, and tenderness, that typically resolve within a few days.
  • The choice between Jalupro and Profhilo depends on individual skin concerns, such as texture and early aging versus hydration and mild laxity. A qualified aesthetic professional should administer the treatment.

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Composition and Mechanism: Jalupro vs Profhilo

Jalupro is a skin rejuvenation injectable that combines non-crosslinked hyaluronic acid with a blend of amino acids, including glycine, proline, leucine, and lysine. This unique formula supports fibroblast activity and promotes the synthesis of new collagen, targeting early signs of aging by facilitating cellular repair and renewal.

for facial rejuvenationfor facial rejuvenation

In contrast, Profhilo consists of 100% pure hyaluronic acid in a patented hybrid complex without amino acids or cross-linking agents. It disperses evenly beneath the skin, providing intense hydration and improved elasticity without volumizing effects. Acting more as a biostimulant than a filler, Profhilo stimulates both collagen and elastin production through a process known as bio-remodeling.

While both are injectable skin boosters, Jalupro emphasizes collagen regeneration supported by amino acids, whereas Profhilo primarily enhances skin hydration and firmness through its innovative HA formulation.

Clinical Indications and Treatment Areas

Jalupro targets concerns such as fine lines, dullness, and photoaging, making it well-suited for improving skin texture and tone. Common treatment zones include the face, neck, hands, décolletage, under-eye area, and even stretch marks. Its amino acid-rich formula is ideal for patients in their late 20s to early 40s seeking either preventive or corrective care.

Conversely, Profhilo is favored for addressing hydration deficits and skin laxity, often applied to the cheeks, jawline, neck, upper arms, and hands. It is best suited for individuals aged 30 to 60+ with mild sagging who desire a subtle lift without added volume. Profhilo’s ability to spread evenly makes it particularly effective for larger areas where dehydration and loss of firmness are more evident.

Treatment Protocols and Patient Experience

Both Jalupro and Profhilo improve skin quality by boosting hydration and stimulating collagen production, but their protocols differ:

Jalupro Treatment Protocol

The patient showed noticeable skin improvement one month after a single Jalupro Super Hydro treatment, thanks to personalized application techniques and tailored biorevitalization based on skin needs and structure.

her new lookher new look
Image Courtesy of Jalupro Official via Instagram
  • Assessment: Evaluate skin condition and determine suitable injection points.
  • Preparation: Cleanse the skin and apply numbing cream if needed.
  • Injection Process: Administer a series of small injections targeting areas needing rejuvenation.
  • Frequency: Typically performed in multiple sessions, spaced over several weeks.
  • Post-Treatment Care: Avoid sun exposure, excessive touching, and follow skincare recommendations.

Patients often report gradual skin improvements, with noticeable results after completing the full treatment course.

Profhilo Treatment Protocol

Following two Profhilo treatments within a month, the patient experienced improved skin hydration, firmer texture, and increased radiance, reflecting the treatment’s effectiveness in enhancing overall skin quality.

she's loveliershe's lovelier
Image Courtesy of Puriva Aesthetic & Lifestyle Clinic Bali via Instagram
  • Consultation: Assess skin laxity and plan strategic injection points.
  • Preparation: Cleanse the skin and ensure proper sterilization.
  • Injection Method: Use the five-point bio-remodeling technique for even product distribution.
  • Session Schedule: Two treatments spaced one month apart for optimal results.
  • Aftercare: Minimal downtime; mild redness or swelling subsides within days.

Profhilo patients often experience rapid improvements in hydration and firmness within days, with peak results typically occurring around 4 to 6 weeks.

Efficacy, Safety, and Side Effects

When administered by trained professionals, both Jalupro and Profhilo have strong safety profiles. Neither contains cross-linked HA, reducing the risks of nodules or delayed reactions.

Many patients inquire, “how long does Profhilo last?” Typically, Profhilo’s effects last for approximately six months, although maintenance treatments may be recommended depending on skin response.

Common side effects include:

  • Mild redness or swelling at injection sites
  • Temporary tenderness or bruising
  • Itching or minor irritation

Jalupro tends to produce gradual improvements in skin tone and texture, peaking after completing the treatment series. Profhilo delivers faster noticeable results in skin hydration and firmness, but also requires maintenance for sustained benefits.

Conclusion

Selecting between Jalupro and Profhilo largely depends on the patient’s skin concerns and desired outcomes. Jalupro excels in improving texture and treating early signs of aging, thanks to its amino acid-enriched formula. Profhilo is optimal for patients prioritizing deep hydration and subtle skin lifting without volume addition.

Patients with fine lines and dull skin may benefit more from Jalupro, while those with mild sagging or volume loss should consider Profhilo. A thorough consultation with an experienced practitioner is crucial for tailoring treatment plans and achieving the best possible results.

FAQs

1. How long does Profhilo last?

Results typically last around 6 months. Some patients extend the benefits with touch-up sessions every 6–9 months.

2. Is Profhilo a dermal filler?

No, Profhilo is not a filler. It doesn’t add volume but rather hydrates and improves skin quality from within.

3. When will I see results from Profhilo?

Most patients notice improvement in hydration and skin glow within a week. Full results usually develop in 4–6 weeks.

4. Can Profhilo be combined with other treatments?

Yes. Practitioners can safely combine it with treatments like Botox, fillers, microneedling, or lasers to enhance results.

5. Who is a good candidate for Profhilo?

Ideal candidates are adults with mild to moderate skin laxity and dehydration. It’s safe for most skin types.

6. Are there any side effects?

Mild redness, swelling, or bruising at the injection site is possible, but these effects are short-lived.

7. How many sessions are required?

The standard protocol is two sessions, spaced four weeks apart. Maintenance is recommended every 6–12 months.

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References

Zile T, Choudhari N, Pohane D, Dhawale T, Mojankar V. HYALURONIC ACID USED IN COSMETICS AND COSMECEUTICALS: A REVIEW. 2023;11:2320-2882. https://ijcrt.org/papers/IJCRT2308010.pdf 

Chylińska N, Maciejczyk M. Hyaluronic acid and skin: Its role in aging and Wound-Healing processes. Gels. 2025;11(4):281. doi:10.3390/gels11040281


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